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1. (WO2018220108) BIOMARKER MOLECULES FOR SARCOPENIA AND USES THEREOF

Pub. No.:    WO/2018/220108    International Application No.:    PCT/EP2018/064331
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: G01N 33/68
C12Q 1/06
Applicants: ARTIALIS SA
Inventors: HENROTIN, Yves
CORNET, Anne
BOULANGER, Benoit
PIRLOT, Céline
Title: BIOMARKER MOLECULES FOR SARCOPENIA AND USES THEREOF
Abstract:
The present invention relates to the identification of novel protein biomarkers for the detection and monitoring of sarcopenia in humans, in the absence of any underlying disease which could affect muscle mass or muscular strength. It is in particular demonstrated that specific fragments of the fructose bisphosphate aldolase A protein are significantly overexpressed in sarcopenia patients. The present invention additionally describes methods and devices to assay said biomarker molecules in human samples, and provide means for generating binding agents against said biomarker molecules.