Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018220106) BIOMARKER MOLECULES FOR SARCOPENIA AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/220106 International Application No.: PCT/EP2018/064328
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
G01N 33/68 (2006.01)
[IPC code unknown for G01N 33/68]
Applicants:
ARTIALIS SA [BE/BE]; Avenue de l'Hôpital, 11, B34 (+3) 4000 Liège, BE
Inventors:
HENROTIN, Yves; BE
CORNET, Anne; BE
BOULANGER, Benoit; BE
PIRLOT, Céline; BE
Agent:
NEDERLANDSCH OCTROOIBUREAU; P.O.Box 29720 2502 LS The Hague, NL
Priority Data:
17173773.731.05.2017EP
Title (EN) BIOMARKER MOLECULES FOR SARCOPENIA AND USES THEREOF
(FR) MOLÉCULES DE BIOMARQUEURS POUR LA SARCOPÉNIE ET LEURS UTILISATIONS
Abstract:
(EN) The present invention relates to the identification of novel protein biomarkers for the detection and monitoring of sarcopenia in humans, in the absence of any underlying disease which could affect muscle mass or muscular strength. It is in particular demonstrated that specific forms of the non- mature Cathepsin D protein are significantly overexpressed in sarcopenia patients. The present invention additionally describes methods and devices to assay said biomarker molecules in human samples, and provide means for generating binding agents against said biomarker molecules.
(FR) L'invention concerne l'identification de nouveaux biomarqueurs protéiques pour la détection et la surveillance de la sarcopénie chez l'être humain, en l'absence de toute maladie sous-jacente susceptible d'affecter la masse musculaire ou la force musculaire. Il est en particulier démontré que des formes spécifiques de la protéine cathepsine D non mature sont significativement surexprimées chez les patients atteints de sarcopénie. La présente invention concerne également des procédés et des dispositifs pour doser lesdites molécules de biomarqueurs dans des échantillons humains et fournir des moyens destinés à générer des agents de liaison contre lesdites molécules de biomarqueurs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)