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1. (WO2018220104) METHOD OF PRODUCING STREPTOCOCCUS THERMOPHILUS MUTANT STRAINS

Pub. No.:    WO/2018/220104    International Application No.:    PCT/EP2018/064325
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: C12N 1/20
C12N 15/01
C12P 1/04
C12R 1/46
A23C 9/12
A23C 9/123
Applicants: CHR. HANSEN A/S
Inventors: TRIHAAS, Jeorgos
JANZEN, Thomas
DERKX, Patrick
Title: METHOD OF PRODUCING STREPTOCOCCUS THERMOPHILUS MUTANT STRAINS
Abstract:
The present invention is directed to a method of producing a Streptococcus thermophilus strain comprising the steps of a) Providing a mother strain in the form of Streptococcus thermophilus DSM32502, b) Growing a culture of the mother strain in the presence of a bacteriophage, to which the mother strain is not resistant, to obtain a number of mutant strains, which are resistant to the said bacteriophage, c) Measuring the acidification time of the bacteriophage-resistant mutant strains and the mother strain in a milk base and selecting at least one mutant strain with a reduced acidification time as compared to the mother strain to obtain a fast-acidifying mutant strain.