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1. (WO2018220080) POLYPEPTIDES ANTAGONIZING WNT SIGNALING IN TUMOR CELLS

Pub. No.:    WO/2018/220080    International Application No.:    PCT/EP2018/064295
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C07K 16/18
C07K 16/28
C07K 16/46
A61K 39/00
A61P 35/00
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors: ZINZALLA, Vittoria
KUENKELE, Klaus-Peter
BUYSE, Marie-Ange
CROMIE, Karen
STAELENS, Stephanie
STRUBBE, Beatrijs
Title: POLYPEPTIDES ANTAGONIZING WNT SIGNALING IN TUMOR CELLS
Abstract:
The invention provides novel LRP5-binding polypeptides, and more specifically novel LRP5-binding immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.