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1. (WO2018220040) TREATMENT PARADIGM FOR AN ANTI-CD19 ANTIBODY AND VENETOCLAX COMBINATION TREATMENT

Pub. No.:    WO/2018/220040    International Application No.:    PCT/EP2018/064229
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 39/395
A61K 31/00
C07K 16/28
A61P 35/00
Applicants: MORPHOSYS AG
Inventors: KELEMEN, Peter
SCHWARZ, Michael
WINDERLICH, Mark
HEEGER, Steffen
WEINELT, Dominika
Title: TREATMENT PARADIGM FOR AN ANTI-CD19 ANTIBODY AND VENETOCLAX COMBINATION TREATMENT
Abstract:
The present disclosure provides anti-CD19 antibodies and venetoclax for use in the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or small lymphocytic lymphoma. The anti-CD19 antibodies, in particular MOR00208, and venetoclax are administered to patients suffering non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL) and/or small lymphocytic lymphoma (SLL) according to a specific treatment paradigm to mitigate therapy associated tumor lysis syndrome.