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1. (WO2018220038) lncRNAs GADLOR 1 AND 2 FOR USE IN TREATING AND PREVENTING CARDIAC REMODELLING

Pub. No.:    WO/2018/220038    International Application No.:    PCT/EP2018/064226
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C12N 15/113
A61P 9/00
Applicants: MEDIZINISCHE HOCHSCHULE HANNOVER
Inventors: HEINEKE, Jörg
FROESE, Natali
Title: lncRNAs GADLOR 1 AND 2 FOR USE IN TREATING AND PREVENTING CARDIAC REMODELLING
Abstract:
The present invention relates to a compound inhibiting the expression and/or the activity of a long non-coding RNA (IncRNA) selected from GADLOR 1 and GADLOR 2 for use in treating or preventing cardiac remodelling, wherein GADLOR 1 comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs 1 to 3 and sequences being at least 75% identical thereto, and GADLOR 2 comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs 4 to 6 and sequences being at least 75% identical thereto.