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1. (WO2018220034) ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION

Pub. No.:    WO/2018/220034    International Application No.:    PCT/EP2018/064221
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C12N 15/113
A61K 31/712
A61K 31/7125
A61P 27/02
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: SÁNCHEZ, Rubén Alvarez
IACONE, Roberto
HAGEDORN, Peter
KAMMLER, Susanne
OTTOSEN, Søren
TRAUSTASON, Sindri
HUDLEBUSCH, Heidi Rye
PEDERSEN, Lykke
BERRERA, Marco
DIECKMANN, Andreas
Title: ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION
Abstract:
The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading to modulation of the expression of HTRA1. Modulation of HTRA expression is beneficial for a range of medical disorders, such as macular degeneration, e.g. age-related macular degeneration.