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1. (WO2018220004) MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS
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Pub. No.: WO/2018/220004 International Application No.: PCT/EP2018/064172
Publication Date: 06.12.2018 International Filing Date: 30.05.2018
IPC:
C12Q 1/6851 (2018.01) ,C12Q 1/6886 (2018.01)
[IPC code unknown for C12Q 1/6851][IPC code unknown for C12Q 1/6886]
Applicants:
ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Straße 116 68305 Mannheim, DE (DE)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
ROCHE MOLECULAR SYSTEMS, INC. [US/US]; 4300 Hacienda Drive Pleasanton, California 94588, US (US)
Inventors:
BEGOVICH, Ann; US
CHEUNG, Cindy; US
CHI, Javelin; US
HILLMAN, Grantland; US
KUO, Dwight; US
LEE, Michael; US
MA, Xiaoju Max; US
MANOHAR, Chitra; US
ORDINARIO, Ellen; US
RAJAMANI, Jaya; US
TRUONG, Huan; US
Agent:
SCHWARZ, Ralf; DE
IMMENDOERFER-RUEHLE, Ulrike; DE
KNAUER, Martin; DE
LOHE, Hans-Joerg; DE
MUSSAUER, Heiko; DE
RAUSCHER, Andreas; DE
VON CAMPENHAUSEN, Harald; DE
HOEVELMANN, Sascha; DE
RIWOTZKI, Karsten; DE
KUNSTMANN, Tobias; DE
RITTER, Claudia; DE
MEINEL, Anne Julia; DE
MOLNAR, Ferenc; DE
Priority Data:
62/513,22631.05.2017US
Title (EN) MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS
(FR) DÉTECTION PAR PCR MULTIPLEX DE FUSIONS D'ALK, RET ET ROS
Abstract:
(EN) Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
(FR) L'invention concerne des méthodes et des compositions pour la détection multiplex d'un grand nombre de fusions de gènes activables avec une sensibilité et une spécificité très élevées. Les présentes méthodes et compositions peuvent détecter des fusions de gènes ALK, RET et ROS1, éventuellement en combinaison avec d'autres mutations et fusions.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)