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1. (WO2018219997) CATALYSTS FOR REVERSING FORMALDEHYDE ADDUCTS AND CROSSLINKS

Pub. No.:    WO/2018/219997    International Application No.:    PCT/EP2018/064161
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: G01N 1/30
Applicants: ROCHE DIAGNOSTICS GMBH
F. HOFFMANN-LA ROCHE AG
ROCHE MOLECULAR SYSTEMS, INC.
Inventors: NIERTH, Alexander
Title: CATALYSTS FOR REVERSING FORMALDEHYDE ADDUCTS AND CROSSLINKS
Abstract:
Catalysts act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting catalysts to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.