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1. (WO2018219968) CELL CULTURE METHODS

Pub. No.:    WO/2018/219968    International Application No.:    PCT/EP2018/064102
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: C12N 5/00
C12P 21/02
C07K 16/00
Applicants: UCB BIOPHARMA SPRL
Inventors: BEN YAHIA, Bassem
MALPHETTES, Laetitia
KOCHANOWSKI, Nadine
RENNER, Gill
DURRAN, Sandrine
YATES, Andrew Jeffrey
Title: CELL CULTURE METHODS
Abstract:
The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.