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1. (WO2018219959) CD8 T CELL SUBSETS AS A BIOMARKER FOR PREDICTING NON-FUSION AFTER SPINAL FUSION SURGERY

Pub. No.:    WO/2018/219959    International Application No.:    PCT/EP2018/064085
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: G01N 33/569
A61K 38/00
Applicants: CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
Inventors: REINKE, Simon
GEIßLER, Sven
DUDA, Georg
VOLK, Hans-Dieter
FUCHS, Michael
SCHMIDT-BLEEK, Katharina
STRUBE, Patrick
PUMBERGER, Matthias
Title: CD8 T CELL SUBSETS AS A BIOMARKER FOR PREDICTING NON-FUSION AFTER SPINAL FUSION SURGERY
Abstract:
The present invention relates to a method for predicting the probability of having or developing a non-fusion, wherein said method comprises determining the frequency of a subpopulation of CD8+ T cells selected from CD8+CD57+, CD8+CD28- and CD8+CD57+CD28- in a sample obtained from a patient. The invention further relates to a system for predicting the probability of having or developing a non-fusion.