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1. (WO2018219801) IMMEDIATE-RELEASE EXTRUDATES

Pub. No.:    WO/2018/219801    International Application No.:    PCT/EP2018/063775
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat May 26 01:59:59 CEST 2018
IPC: A61K 9/14
A61K 31/4439
Applicants: BAYER PHARMA AKTIENGESELLSCHAFT
Inventors: TEREBESI, Ildiko
SERNO, Peter
SANDMANN, Steffen
FREUNDLIEB, Julia
STROYER, Anke
PIES, Tanja
Title: IMMEDIATE-RELEASE EXTRUDATES
Abstract:
The present invention relates to stable transparent compositions in form of rapid release melt extrudates that contain selective partial adenosine A1 receptor agonists as active pharmaceutical ingredients, a polymeric compound as excipient and optionally a water-soluble sugar alcohol. This invention also relates to a solvent-free process of preparing said extrudates as well as the use of said extrudates in the production of rapid release preparations.