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1. WO2018219619 - METHOD FOR MODIFYING MICROCYSTINS AND NODULARINS

Publication Number WO/2018/219619
Publication Date 06.12.2018
International Application No. PCT/EP2018/062156
International Filing Date 09.05.2018
Chapter 2 Demand Filed 08.03.2019
IPC
C12P 13/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
C12P 21/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
04Cyclic or bridged peptides or polypeptides, e.g. bacitracin
C07D 259/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
259Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
C07K 7/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
58Bacitracins; Related peptides
CPC
C07K 7/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
58Bacitracins; Related peptides
C12P 13/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
Applicants
  • CYANO BIOTECH GMBH [DE]/[DE]
Inventors
  • ENKE, Heike
  • LORENZEN, Wolfram
  • JAHNS, Stefan
  • ENKE, Dan
  • NIEDERMEYER, Timo
  • MOSCHNY, Julia
Agents
  • ANDRESEN, Heiko
Priority Data
17170284.809.05.2017EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR MODIFYING MICROCYSTINS AND NODULARINS
(FR) PROCÉDÉ DE MODIFICATION DE MICROCYSTINES ET DE NODULARINES
Abstract
(EN)
The invention relates to a method of producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), comprising the steps of: a) growing a modified non-ribosomal peptide producing cyanobacteria strain in a culture media, b) adding one or more modified substrates preferably modified amino acids to said culture, and c) inoculating the non- ribosomal peptide producing strain the presence of said modified substrates. The thus modified non- ribosomal peptide may be used for the therapy of various diseases.
(FR)
L'invention concerne un procédé de production d'un peptide non ribosomique modifié, par exemple une microcystine modifiée et/ou une nodularine modifiée (conjointement CA), comprenant les étapes suivantes : a) croissance d'un peptide non ribosomique modifié produisant une souche de cyanobactéries dans un milieu de culture, b) ajout d'un ou plusieurs substrats modifiés de préférence des acides aminés modifiés à ladite culture, et c) inoculation de la souche produisant le peptide non ribosomique en présence desdits substrats modifiés. Le peptide non ribosomique ainsi modifié peut être utilisé pour la thérapie de différentes maladies.
Also published as
IL270522
Latest bibliographic data on file with the International Bureau