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1. (WO2018219356) FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
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Pub. No.: WO/2018/219356 International Application No.: PCT/CN2018/089699
Publication Date: 06.12.2018 International Filing Date: 02.06.2018
IPC:
C07D 471/04 (2006.01) ,C07D 455/06 (2006.01) ,A61K 31/435 (2006.01) ,A61K 31/4375 (2006.01) ,A61K 31/5025 (2006.01) ,A61P 31/12 (2006.01) ,A61P 31/20 (2006.01)
[IPC code unknown for C07D 471/04][IPC code unknown for C07D 455/06][IPC code unknown for A61K 31/435][IPC code unknown for A61K 31/4375][IPC code unknown for A61K 31/5025][IPC code unknown for A61P 31/12][IPC code unknown for A61P 31/20]
Applicants:
SUNSHINE LAKE PHARMA CO., LTD. [CN/CN]; Northern Industrial Area, Songshan Lake Dongguan, Guangdong 523000, CN
Inventors:
LIU, Xinchang; CN
REN, Qingyun; CN
HUANG, Jianzhou; CN
XIONG, Zhimin; CN
XIONG, Jinfeng; CN
LI, You; CN
LIU, Yang; CN
ZOU, Zhifu; CN
YAN, Guanghua; CN
GOLDMANN, Siegfried; CN
ZHANG, Yingjun; CN
Agent:
TSINGYIHUA INTELLECTUAL PROPERTY LLC; Room 301 Trade Building, Zhaolanyuan, Tsinghua University, Qinghuayuan, Haidian District Beijing 100084, CN
Priority Data:
201710403592.501.06.2017CN
201711170576.222.11.2017CN
Title (EN) FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
(FR) COMPOSÉS TRYCICLIQUES CONDENSÉS ET UTILISATIONS CORRESPONDANTES EN MÉDECINE
Abstract:
(EN) The present invention relates to a fused tricyclic compound and use thereof as a medicament, in particular as a medicament for the treatment and/or prevention of hepatitis B. Specifically, the invention relates to a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in specification. The invention also relates to the use of the compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.
(FR) La présente invention concerne un composé tricyclique condensé et une utilisation correspondante en tant que médicament, en particulier en tant que médicament pour le traitement et/ou la prévention de l'hépatite B. Plus particulièrement, l'invention concerne un composé de formule (I) ou un stéréoisomère, un tautomère, un N-oxyde, un solvate, un métabolite, un sel pharmaceutiquement acceptable ou un promédicament correspondant, chaque variant étant tel que défini dans la description. L'invention concerne également l'utilisation du composé de formule (I) ou d'un stéréoisomère, d'un tautomère, d'un N-oxyde, d'un solvate, d'un métabolite, d'un sel pharmaceutiquement acceptable ou d'un promédicament correspondant en tant que médicament, en particulier en tant que médicament pour le traitement et/ou la prévention de l'hépatite B.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)