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|1. (WO2018219301) PDGFRβ-TARGETED TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND VARIANT, PREPARATION METHOD THEREFOR AND USE THEREOF|
|Applicants:||WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
|Title:||PDGFRβ-TARGETED TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND VARIANT, PREPARATION METHOD THEREFOR AND USE THEREOF|
Disclosed is a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and ZPDGFRβ. ZPDGFRβ is connected to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by means of a connexon. Also disclosed are a nucleotide sequence and a recombinant vector and recombinant bacteria thereof, as well as a preparation method for and a use of the variant above. The TRAIL variant protein Z-hTRAIL in the present invention has excellent tumor-killing activity, also shows an explicit curative effect on hepatic fibrosis, and has a wide prospect in clinical application.