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1. (WO2018219301) PDGFRβ-TARGETED TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND VARIANT, PREPARATION METHOD THEREFOR AND USE THEREOF

Pub. No.:    WO/2018/219301    International Application No.:    PCT/CN2018/089069
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C07K 19/00
C12N 15/09
A61K 38/16
A61P 35/00
A61P 37/06
Applicants: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
四川大学华西医院
Inventors: TAO, Ze
陶泽
YANG, Hao
杨浩
LU, Xiaofeng
卢晓风
Title: PDGFRβ-TARGETED TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND VARIANT, PREPARATION METHOD THEREFOR AND USE THEREOF
Abstract:
Disclosed is a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and ZPDGFRβ. ZPDGFRβ is connected to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by means of a connexon. Also disclosed are a nucleotide sequence and a recombinant vector and recombinant bacteria thereof, as well as a preparation method for and a use of the variant above. The TRAIL variant protein Z-hTRAIL in the present invention has excellent tumor-killing activity, also shows an explicit curative effect on hepatic fibrosis, and has a wide prospect in clinical application.