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1. (WO2018219299) COMPOSITIONS AND METHODS OF CELLULAR IMMUNOTHERAPY

Pub. No.:    WO/2018/219299    International Application No.:    PCT/CN2018/089061
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C07K 16/30
C12N 15/62
A61K 38/16
A61P 35/00
Applicants: CARSGEN THERAPEUTICS CO., LTD.
SHANGHAI CANCER INSTITUTE
Inventors: LI, Zonghai
WANG, Peng
JIANG, Hua
Title: COMPOSITIONS AND METHODS OF CELLULAR IMMUNOTHERAPY
Abstract:
Disclosed herein are methods of treating a subject exhibiting a cell that expresses Wilms tumor protein 1 (WT1). The methods typically utilize anti-WT1 antigen binding units or chimeric antigen receptor immunoresponsive cells to a subject in need thereof to effect killing of tumor cells.