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1. (WO2018219295) DEUTERATED 1,2,4-TRIAZINE DERIVATIVES OF DIPEPTIDYL PEPTIDASE IV INHIBITOR
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Pub. No.: WO/2018/219295 International Application No.: PCT/CN2018/089027
Publication Date: 06.12.2018 International Filing Date: 30.05.2018
IPC:
C07D 401/04 (2006.01) ,A61K 31/53 (2006.01) ,A61P 3/10 (2006.01)
[IPC code unknown for C07D 401/04][IPC code unknown for A61K 31/53][IPC code unknown for A61P 3/10]
Applicants:
深圳信立泰药业股份有限公司 SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD [CN/CN]; 中国广东省深圳市 深圳信立泰药业股份有限公司37层 37 F, Main Tower, Lvjing plaza, Che Gong Miao No. 6009 Shennan Road, Futian District Shenzhen, Guangdong 518040, CN
Inventors:
刘刚 LIU, Gang; CN
李硕 LI, Shuo; CN
温晓明 WEN, Xiaoming; CN
胡春云 HU, Chunyun; CN
黄伟鑫 HUANG, Weixin; CN
Priority Data:
201710397117.131.05.2017CN
Title (EN) DEUTERATED 1,2,4-TRIAZINE DERIVATIVES OF DIPEPTIDYL PEPTIDASE IV INHIBITOR
(FR) DÉRIVÉS DE 1,2,4-TRIAZINE DEUTÉRÉS DE L'INHIBITEUR DE LA DIPEPTIDYLE PEPTIDASE IV
(ZH) 二肽基肽酶IV抑制剂的氘代1,2,4-三嗪衍生物
Abstract:
(EN) Substituted 1,2,4-triazine derivatives of a dipeptidyl peptidase IV (DPP-IV) inhibitor. The derivatives have the following structural formula (IR); in the formula, part or all of hydrogen in R 1-R 19 is substituted by diplogen. The derivatives can be used to prepare a medicine for ameliorating or treating diabetes.
(FR) L'invention concerne des dérivés de 1,2,4-triazine substitués d'un inhibiteur de la dipeptidyle peptidase IV (DPP-IV). Les dérivés ont la formule développée suivante (IR) ; dans la formule, une partie ou la totalité de l'hydrogène dans R 1-R 19 est substituée par diplogène. Les dérivés de l'invention peuvent être utilisés dans la préparation d'un médicament pour atténuer ou traiter le diabète.
(ZH) 二肽基肽酶IV(DPP-IV)抑制剂的取代1,2,4-三嗪衍生物,所述衍生物具有以下结构式(IR),其中R 1-R 19的部分或者全部氢被氘取代,其可用于制备改善或治疗糖尿病的药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)