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1. (WO2018219281) 4-PYRIMIDINEDIAMINE SMALL MOLECULAR ORGANIC COMPOUNDS AND DERIVATIVES THEREOF AND USE THEREOF

Pub. No.:    WO/2018/219281    International Application No.:    PCT/CN2018/088932
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C07D 239/48
A61P 35/00
A61P 29/00
Applicants: EAST CHINA NORMAL UNIVERSITY
华东师范大学
BIORAY LABORATORIES INC
上海邦耀生物科技有限公司
Inventors: CHEN, Yihua
陈益华
LIU, Mingyao
刘明耀
GUO, Weikai
郭伟凯
XING, Yajing
邢雅婧
HUANG, Dongxia
黄懂霞
YI, Zhengfang
易正芳
DU, Bing
杜冰
ZHANG, Qiansen
张乾森
Title: 4-PYRIMIDINEDIAMINE SMALL MOLECULAR ORGANIC COMPOUNDS AND DERIVATIVES THEREOF AND USE THEREOF
Abstract:
Disclosed is a class of 4-pyrimidinediamine small molecular organic compounds or related analogues or pharmaceutically acceptable salts thereof, with the structures thereof as shown in formulae (I)-(VI). Also disclosed are the use of the 4-pyrimidinediamine small molecular organic compounds or pharmaceutical compositions thereof in the preparation of drugs for preventing and/or treating various malignant tumours, autoimmune diseases, inflammation, etc., and the use of same as an inhibitor of B cell lymphokine 6 (BCL6) in the preparation of a drug for preventing and/or treating BCL6-mediated diseases.