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1. (WO2018219266) COMPOSITION FOR PREPARING HEPATITIS B VACCINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Pub. No.:    WO/2018/219266    International Application No.:    PCT/CN2018/088817
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: A61K 39/39
A61K 39/29
A61K 39/385
A61P 1/16
A61P 31/20
A61P 37/02
C07D 473/18
A61K 31/52
Applicants: SHENZHEN UNIVERSITY
深圳大学
SHENZHEN KANGTAI BIOLOGICAL PRODUCTS CO., LTD
深圳康泰生物制品股份有限公司
Inventors: JIN, Guangyi
靳广毅
WANG, Zhulin
王竹林
ZHU, Zhengyu
朱征宇
TANG, Li
唐黎
HU, Yunlong
胡云龙
Title: COMPOSITION FOR PREPARING HEPATITIS B VACCINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Abstract:
A composition for preparing hepatitis B vaccine, a preparation method therefor, and an application thereof. The composition comprises immune agonist activated ester, HBsAg and an aluminum adjuvant. On the basis of maintaining the hepatitis B virus specific antibody of an existing prophylactic vaccine in animal and human body, the composition can perform inactivation and clearance on hepatitis B virus inflected cells, thus having a dual effect of preventing and treating hepatitis B.