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1. (WO2018219204) NOVEL PHENOXUACETIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND USES OF DERIVATIVE AS DRUG
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Pub. No.: WO/2018/219204 International Application No.: PCT/CN2018/088204
Publication Date: 06.12.2018 International Filing Date: 24.05.2018
IPC:
C07C 217/84 (2006.01) ,C07C 255/58 (2006.01) ,C07C 317/18 (2006.01) ,C07D 261/08 (2006.01) ,A61K 31/196 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/42 (2006.01) ,A61P 3/10 (2006.01) ,A61P 3/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
78
having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
80
having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
82
of the same non-condensed six-membered aromatic ring
84
the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
255
Carboxylic acid nitriles
49
having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
58
containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
317
Sulfones; Sulfoxides
16
having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
18
with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
261
Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
02
not condensed with other rings
06
having two or more double bonds between ring members or between ring members and non-ring members
08
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
196
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
中国药科大学 CHINA PHARMACEUTICAL UNIVERSITY [CN/CN]; 中国江苏省南京市 江宁区龙眠大道639号 No.639 Longmian Avenue, Jiangning Nanjing, Jiangsu 211198, CN
Inventors:
钱海 QIAN, Hai; CN
黄文龙 HUANG, Wenlong; CN
刘春霞 LIU, Chunxia; CN
杨建勇 YANG, Jianyong; CN
Agent:
南京思拓知识产权代理事务所(普通合伙) NANJING SITUO INTELLECTUAL PROPERTY AGENCY (GP); 中国江苏省南京市 鼓楼区云南北路49号1508室 1508, No.49 Yunnanbei Road, Gulou District Nanjing, Jiangsu 210009, CN
Priority Data:
201710407580.X27.05.2017CN
Title (EN) NOVEL PHENOXUACETIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND USES OF DERIVATIVE AS DRUG
(FR) NOUVEAU DÉRIVÉ D'ACIDE PHÉNOXYACÉTIQUE, SON PROCÉDÉ DE PRÉPARATION ET SES UTILISATIONS COMME MÉDICAMENT
(ZH) 一类新型苯氧乙酸衍生物、其制备方法及其作为药物的用途
Abstract:
(EN) The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment of diabetes mellitus and metabolic syndrome. The phenoxyacetic acid derivative has excellent in-vivo hypoglycemic activity and therefore can be used for preventing and treating diabetes mellitus.
(FR) La présente invention concerne un nouveau dérivé d'acide phénoxyacétique représenté par la formule générale (I), un procédé de préparation de ce dérivé, ainsi que des utilisations de compositions de médicament contenant ce dérivé dans la préparation de médicament destiné au traitement du diabète sucré et du syndrome métabolique. Ce dérivé d'acide phénoxyacétique possède une excellente activité hypoglycémique in vivo et peut donc être utilisé pour prévenir et traiter le diabète sucré.
(ZH) 本发明涉及一种通式 (I) 所示的新型苯氧乙酸衍生物、其制备方法及含有该衍生物的药物组合物作为制备治疗糖尿病和代谢综合症的药物用途。所述的苯氧乙酸衍生物具有优异的体内降血糖活性,其可以用于预防或治疗糖尿病。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)