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1. (WO2018219188) APPLICATION OF CEFMINOX IN PREPARATION OF MEDICINE FOR PREVENTING/TREATING PULMONARY HYPERTENSION

Pub. No.:    WO/2018/219188    International Application No.:    PCT/CN2018/087993
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 24 01:59:59 CEST 2018
IPC: A61K 31/545
A61K 31/546
A61P 9/12
Applicants: SHANGHAI HOFFEN PHARMACEUTICAL CO., LTD.
上海颢峰医药科技有限公司
Inventors: LIU, Fuyin
刘复银
Title: APPLICATION OF CEFMINOX IN PREPARATION OF MEDICINE FOR PREVENTING/TREATING PULMONARY HYPERTENSION
Abstract:
The present invention provides an application of Cefminox in the preparation of a medicine for preventing/treating pulmonary hypertension. Through pharmacological experiments on the preventive and therapeutic effect of Cefminox on PAH in rats induced by monocrotaline, the inventors confirm that the curative effect of Cefminox is good and significantly better than that of existing medicines in a control group. Cefminox can reduce pulmonary artery pressure at lower doses by pulmonary administration, with a curative effect significantly better than that of intravenous administration. The present invention provides a new medicine for preventing/treating pulmonary hypertension and has a bright clinical application prospect.