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1. (WO2018219108) ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF

Pub. No.:    WO/2018/219108    International Application No.:    PCT/CN2018/086228
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 10 01:59:59 CEST 2018
IPC: C07K 14/00
C07K 17/00
C12P 7/40
Applicants: ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
Inventors: CHEN, Haibin
BONG, Yong Koy
CAI, Baoqin
XU, Qing
SHEN, Tianran
ZHOU, Ameng
YANG, Jiadong
YANG, Zhuhong
JI, Yaoyao
ZHANG, Yingxin
Title: ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF
Abstract:
Provided herein are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. Also provided are polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption.