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|1. (WO2018219108) ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF|
|Applicants:||ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
BONG, Yong Koy
|Title:||ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF|
Provided herein are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. Also provided are polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption.