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1. (WO2018218903) METHOD FOR PREPARING TROXERUTIN ESTER USING WHOLE CELL CATALYSIS

Pub. No.:    WO/2018/218903    International Application No.:    PCT/CN2017/113808
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Dec 01 00:59:59 CET 2017
IPC: C12P 17/06
C12P 7/62
Applicants: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
华南理工大学
Inventors: LI, Xiaofeng
李晓凤
XIN, Xuan
辛璇
ZHAO, Guanglei
赵光磊
Title: METHOD FOR PREPARING TROXERUTIN ESTER USING WHOLE CELL CATALYSIS
Abstract:
A method for preparing troxerutin ester using whole cell catalysis, which falls within the fields of biological catalysis and pharmaceutical chemistry. The method specifically comprises the following steps: evenly mixing troxerutin and a mixed organic solvent containing pyridine, then adding an acyl donor and a whole cell catalyst, and performing oscillating reaction at a reaction temperature of 25-55 °C; and after the reaction has been finished, separating and purifying the product by means of column chromatography or thin-layer chromatography, so as to obtain the troxerutin ester. The method has the advantages of mild reaction conditions, being environmentally friendly, having simple process, fewer side reactions, and high selectivity.