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|1. (WO2018218710) CHIMERIC ANTIGEN RECEPTOR CELLS TARGETING ROBO1, PREPARATION AND APPLICATION THEREOF|
|Applicants:||ASCLEPIUS (SUZHOU) TECHNOLOGY COMPANY GROUP CO., LTD.
|Title:||CHIMERIC ANTIGEN RECEPTOR CELLS TARGETING ROBO1, PREPARATION AND APPLICATION THEREOF|
Provided are chimeric antigen receptor cells targeting ROBO1, in particular, enhanced CAR-T cells and CAR-NK cells targeting ROBO1, and preparation and application thereof. The cells can stably expressing CAR elements, while secreting extracellular domain molecules expressing PD-1 protein or mutants thereof, and thus may bloc PD-1/PD-L1 molecular interaction. It has been found through animal experiments that the cells have very good anti-tumor effects, and the above-mentioned cells can significantly reduce tumor recurrence and improve the survival rate compared with the conventional ROBO1-targeted CAR modified cells.