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1. (WO2018218355) METHOD OF DIAGNOSING FLAVIVIRUS INFECTION

Pub. No.:    WO/2018/218355    International Application No.:    PCT/CA2018/050637
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: G01N 33/48
G01N 1/28
G01N 33/483
G01N 33/569
A61K 31/192
A61K 31/167
Applicants: WESTERN UNIVERSITY
UNIVERSITY OF SÃO PAULO
Inventors: SIQUEIRA, Walter L.
MACHADO, Maria A. M.
HELLER, Debora
Title: METHOD OF DIAGNOSING FLAVIVIRUS INFECTION
Abstract:
A method of detecting Flaviviral peptides in a mammalian saliva sample is provided comprising: obtaining a saliva sample from the mammal; and detecting in the sample the presence of at least two peptides selected from the group consisting of: MDHFSLGVLVILLMVQEGLKKRMTTKIIISTSMAVLVAMILGGFSMSDLAKLAILMGATFAEMNTGGDVAHL; NIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEE; WCNTTSTWVVYGTCHHKKGEARRSRRAVTLPSHSTRKLQTRSQTWLESREYTK; VEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMN; LEIRFEECPGTKVHVEETCGTRGPSLRSTTASGRVIEE; EEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTS; RVEMGEAAAIFMTATPPGTRDAFPDSNSPIMDTEVEVPERAWSSGFDW; and GQVLLIAVAVSSAILSRTAWGWGEAGALITAATSTLWEGSPNKYWNSSTATSLCNIF.