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1. (WO2018218346) NOVEL SYNTHETIC POLYMERS AND CROSSLINKED HYDROGEL SYSTEMS

Pub. No.:    WO/2018/218346    International Application No.:    PCT/CA2018/050627
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: C08F 222/06
C08F 8/36
C08G 81/02
C08J 3/075
C08J 3/24
C08K 5/37
Applicants: MCMASTER UNIVERSITY
Inventors: STEWART, Sarah Alison
STOVER, Harald Donald Helmut
COULSON, Michael Bradley
Title: NOVEL SYNTHETIC POLYMERS AND CROSSLINKED HYDROGEL SYSTEMS
Abstract:
A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol- containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.