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1. (WO2018218344) COMPOSITIONS AND METHODS FOR OBTAINING ORGANOIDS

Pub. No.:    WO/2018/218344    International Application No.:    PCT/CA2018/050625
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: C12N 5/071
A61K 35/36
A61K 35/407
A61L 27/38
A61P 1/16
A61P 1/18
C12N 5/02
C12Q 1/02
C12Q 1/68
G01N 33/48
Applicants: STEMCELL TECHNOLOGIES CANADA INC.
Inventors: SEGERITZ, Charis-Patricia
CONDER, Ryan
RIEDEL, Michael
Title: COMPOSITIONS AND METHODS FOR OBTAINING ORGANOIDS
Abstract:
A method for obtaining epithelial organoids is provided. In one embodiment, the method comprises culturing one or more epithelial ducts, epithelial duct fragments and/or epithelial stem cells isolated therefrom in contact with an extracellular matrix in the presence of a basal medium, wherein the medium is free of FGF and/or nicotinamide. Organoids obtained by the methods described herein, and uses thereof, are also provided.