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1. WO2018214875 - HEPATITIS B VIRUS SURFACE ANTIGEN INHIBITOR

Publication Number WO/2018/214875
Publication Date 29.11.2018
International Application No. PCT/CN2018/087852
International Filing Date 22.05.2018
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 498/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 福建广生堂药业股份有限公司 FUJIAN COSUNTER PHARMACEUTICAL CO., LTD. [CN]/[CN]
  • 南京明德新药研发有限公司 MEDSHINE DISCOVERY INC. [CN]/[CN]
Inventors
  • 丁照中 DING, Charles Z.
  • 孙飞 SUN, Fei
  • 胡彦宾 HU, Yanbin
  • 陈曙辉 CHEN, Shuhui
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
201710365328.722.05.2017CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HEPATITIS B VIRUS SURFACE ANTIGEN INHIBITOR
(FR) INHIBITEUR D'ANTIGÈNE DE SURFACE DU VIRUS DE L'HÉPATITE B
(ZH) 乙型肝炎病毒表面抗原抑制剂
Abstract
(EN)
Disclosed in the present invention is a new 11-oxo-7,11-dihydro-6h-benzo-[f]pyrido[1,2-d][1,4]azepine oxepin-10-carboxylic acid derivative serving as a hepatitis B virus surface antigen inhibitor. Specifically disclosed are a compound represented by formula (V) or a pharmaceutically acceptable salt thereof, and applications of the compound represented by formula (V) or the pharmaceutically acceptable salt thereof and a pharmaceutical composition thereof in the treatment of viral hepatitis B.
(FR)
La présente invention concerne un nouveau dérivé d'acide 11-oxo-7,11-dihydro-6h-benzo-[f]pyrido[1,2-d][1,4]azépine oxépin-10-carboxylique servant d'inhibiteur d'antigène de surface du virus de l'hépatite B. L'invention concerne particulièrement un composé représenté par la formule (V) ou un sel pharmaceutiquement acceptable de celui-ci, et des applications du composé représenté par la formule (V) ou de son sel pharmaceutiquement acceptable ainsi qu'une composition pharmaceutique de celui-ci dans le traitement de l'hépatite B virale.
(ZH)
本发明公开了新的作为乙肝表面抗原抑制剂的11-氧代-7,11-二氢-6H-苯并[f]吡啶并[1,2-d][1,4]氮氧杂卓-10-羧酸衍生物,具体公开了式(V)所示化合物或其药学上可接受的盐,以及式(V)所示化合物或其药学上可接受的盐和药用组合物在治疗乙型病毒性肝炎中的应用。
Also published as
JP2019564542
MXMX/a/2019/013815
SG11201910456Y
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