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1. (WO2018205344) CEA.CAR-T, PREPARATION METHOD THEREFOR AND USE THEREOF

Pub. No.:    WO/2018/205344    International Application No.:    PCT/CN2017/088507
Publication Date: Fri Nov 16 00:59:59 CET 2018 International Filing Date: Fri Jun 16 01:59:59 CEST 2017
IPC: C07K 19/00
C12N 15/62
C12N 5/10
A61K 35/17
A61P 35/00
Applicants: THE FIRST PEOPLE' S HOSPITAL OF CHANGZHOU
常州市第一人民医院
Inventors: JIANG, Jingting
蒋敬庭
LU, Binfeng
卢斌峰
CHEN, Yu'ang
陈宇昂
CHEN, Lujun
陈陆俊
Title: CEA.CAR-T, PREPARATION METHOD THEREFOR AND USE THEREOF
Abstract:
The present invention belongs to the field of biotechnology, and provides a CEA.CAR-T, a preparation method therefor and use thereof. The present invention firstly provides a chimeric antigen receptor targeting a carcinoembryonic antigen, the chimeric antigen receptor comprising polypeptides binding to carcinoembryonic antigen (CEA), CD28 transmembrane domain (CD28-TM), intracellular 4-1BB and intracellular CD3ζ, which are linked in sequence. Then, T cells that can express said chimeric antigen receptor are prepared.