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1. (WO2018205191) INDUSTRIAL PREPARATION METHOD FOR FOUR TYPES OF QUASSIN AND NOVEL APPLICATION OF SAME FOR PREPARATION OF DRUGS AND HEALTH FOOD

Pub. No.:    WO/2018/205191    International Application No.:    PCT/CN2017/083876
Publication Date: Fri Nov 16 00:59:59 CET 2018 International Filing Date: Fri May 12 01:59:59 CEST 2017
IPC: A61K 36/185
A61P 15/00
A61P 15/08
A61P 39/00
A61P 37/04
A61P 19/06
Applicants: BEIJING NOZER BIOTECHNOLOGY CO. LTD
北京罗瑞生物科技有限公司
Inventors: WANG, Huifang
王惠芳
LIU, Yongzhou
刘永周
XIA, Chuandi
夏传递
LIANG, Ke
梁克
JIAO, Yanling
焦燕玲
DONG, Deshun
董德顺
XIAO, Hu
肖虎
Title: INDUSTRIAL PREPARATION METHOD FOR FOUR TYPES OF QUASSIN AND NOVEL APPLICATION OF SAME FOR PREPARATION OF DRUGS AND HEALTH FOOD
Abstract:
An industrial preparation method suitable for extracting four types of quassin ingredient from eurycoma longifolia plants, and an application for preparing products. Ultrasonic countercurrent water extraction and silica gel-low boiling point solvent chromatography are used to separate four types of quassin ingredient from eurycoma longifolia plants and purify same. Any one of the four types of quassin ingredient can be prepared into an oral formulation or an injection solution used for improving male tardive hypogonadism and mild to moderate depression. The present production method has strong continuity, and is large scale, highly safe, and suitable for industrial amplification; the product has good stability, high purity, high product quality, and no residual toxic solvents; and the drug has great potential for application, meriting in-depth development.