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1. (WO2018205035) GENETIC SIGNATURES TO PREDICT PROSTATE CANCER METASTASIS AND IDENTIFY TUMOR AGRESSIVENESS

Pub. No.:    WO/2018/205035    International Application No.:    PCT/CA2018/050563
Publication Date: Fri Nov 16 00:59:59 CET 2018 International Filing Date: Sat May 12 01:59:59 CEST 2018
IPC: C12Q 1/6809
C12Q 1/6837
C12Q 1/6841
C12Q 1/686
C40B 30/04
C40B 30/06
G01N 33/48
G01N 33/574
Applicants: GENOMEDX BIOSCIENCES, INC
Inventors: DAVICIONI, Elai
ERHO, Nicholas
ASHAB, Hussam Al-Deen
ALSHALALFA, Mohammed
Title: GENETIC SIGNATURES TO PREDICT PROSTATE CANCER METASTASIS AND IDENTIFY TUMOR AGRESSIVENESS
Abstract:
The present invention relates to methods, systems and kits for the diagnosis, prognosis and the determination of cancer progression of prostate cancer in a subject. The invention also provides clinically useful genomic classifiers for predicting prostate cancer metastasis and identifying tumor aggressiveness. The methods, systems and kits can provide expression-based analysis of biomarkers for purposes of predicting metastatic disease and lethal prostate cancer in a subject. Further disclosed herein, in certain instances, are probe sets for use in predicting prostate cancer metastasis in a subject. Classifiers for predicting prostate cancer metastasis are provided. Methods of treating cancer based on tumor aggressiveness are also provided. The methods and classifiers of the present invention are also useful for predicting early prostate cancer metastasis.