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1. (WO2018204976) ANTI-INFLAMMATORY AGENTS AND METHODS OF TREATMENT

Pub. No.:    WO/2018/204976    International Application No.:    PCT/AU2018/050427
Publication Date: Fri Nov 16 00:59:59 CET 2018 International Filing Date: Thu May 10 01:59:59 CEST 2018
IPC: A61K 39/395
A61K 38/00
A61P 29/00
A61P 37/06
A61P 37/02
Applicants: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Inventors: RAMM, Grant
FERNANDEZ-ROJO, Manuel Alejandro
Title: ANTI-INFLAMMATORY AGENTS AND METHODS OF TREATMENT
Abstract:
Disclosed are agents for treating or preventing inflammatory diseases and/or conditions. More particularly, the present invention discloses the use of ICAM-1 antagonists, including ICAM-1 antigen-binding molecules, for treating inflammatory diseases including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In specific embodiments, the ICAM-1 antagonists are used in combination with immunotherapeutic agents to inhibit an inflammatory immune response.