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1. (WO2018204893) METHODS AND COMPOSITIONS FOR TREATING LIVER DISEASE

Pub. No.:    WO/2018/204893    International Application No.:    PCT/US2018/031261
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sat May 05 01:59:59 CEST 2018
IPC: A61K 38/00
A61K 38/22
A61P 1/16
C07K 14/575
C07K 14/645
C07K 14/705
Applicants: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors: ALPINI, Gianfranco
GLASER, Shannon S.
MENG, Fanyin
Title: METHODS AND COMPOSITIONS FOR TREATING LIVER DISEASE
Abstract:
Disclosed is a method of modulating the Sct/SR axis in a mammalian subject in need thereof, including in a subject suffering from a liver disease, such as but not limited to, Early Stage PBC, Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, Biliary Atresia, NASH, NAFLD, or Alcohol induced liver injury. A method of treating Late Stage PBC in a mammalian subject in need thereof is also disclosed; further disclosed is a method of ameliorating PBC-induced biliary damage in a mammalian subject in need thereof. Pharmaceutical compositions for modulating the Sct/SR axis, comprising a SR antagonist or a SR agonist, and a pharmaceutically acceptable carrier or excipient are also disclosed.