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1. (WO2018204871) METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISORDERS

Pub. No.:    WO/2018/204871    International Application No.:    PCT/US2018/031231
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sat May 05 01:59:59 CEST 2018
IPC: A61K 39/395
A61P 1/00
A61P 37/00
C07K 16/28
Applicants: ALLAKOS INC.
Inventors: BEBBINGTON, Christopher Robert
YOUNGBLOOD, Bradford Andrew
TOMASEVIC, Nenad
BROCK, Emily C.
Title: METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISORDERS
Abstract:
The present disclosure provides methods for the treatment of inflammatory bowel disease (IBD) or an eosinophilic gastrointestinal disorder (EGID), such as eosinophilic esophagitis (EOE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). In particular, the present disclosure provides methods for the treatment of IBD or an EGID through administration of antibodies that bind to human Siglec-8 or compositions comprising said antibodies. The present disclosure also provides articles of manufacture or kits comprising antibodies that bind to human Siglec-8 for the treatment of IBD or an EGID.