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1. (WO2018204830) INHIBITING SENESCENT PROCESSES IN BETA CELLS FOR THE PREVENTION OF TYPE 1 DIABETES

Pub. No.:    WO/2018/204830    International Application No.:    PCT/US2018/031161
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sat May 05 01:59:59 CEST 2018
IPC: A61K 31/496
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: BHUSHAN, Anil
Title: INHIBITING SENESCENT PROCESSES IN BETA CELLS FOR THE PREVENTION OF TYPE 1 DIABETES
Abstract:
The inventor of the present disclosure has advantageously elucidated the role of senescent processes in the development of Type 1 diabetes. Genotoxic stress responses, senescence, and acquisition of a SASP condition in beta cells are drivers that progress at-risk individuals to overt Type 1 diabetes. The administration of senolytic agents to at risk individuals selectively removes senescent cells and relieves beta cells from the factors which drive the development of overt Type 1 diabetes. Accordingly, Type 1 diabetes can be prevented in at-risk individuals by the administration of senolytic compositions. Additionally, given the major role of SASP in the development of Type 1 diabetes, the inhibition of SASP factors may be used to prevent Type 1 diabetes.