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1. (WO2018204829) METHODS FOR PREVENTING NEURAL TUBE DEFECTS IN DIABETIC PREGNANCY
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Pub. No.: WO/2018/204829 International Application No.: PCT/US2018/031159
Publication Date: 08.11.2018 International Filing Date: 04.05.2018
IPC:
A61K 31/4745 (2006.01) ,A61K 31/74 (2006.01) ,A61K 39/395 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4738
ortho- or peri-condensed with heterocyclic ring systems
4745
condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
74
Synthetic polymeric materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
YANG, Peixin [US/US]; US (US)
REECE, Albert, E. [US/US]; US (US)
SHEN, Wei-Bin [US/US]; US (US)
UNIVERSITY OF MARYLAND, BALTIMORE [US/US]; 620 West Lexington Street, 4th Floor Baltimore, MD 21201, US (AllExceptUS)
Inventors:
YANG, Peixin; US
REECE, Albert, E.; US
SHEN, Wei-Bin; US
Agent:
FONVILLE, Natalie; US
HAAS, Dennis; US
ALLEN, Justin; US
ARTIS, Ryan; US
CHEN, Ming; US
Priority Data:
62/501,39804.05.2017US
Title (EN) METHODS FOR PREVENTING NEURAL TUBE DEFECTS IN DIABETIC PREGNANCY
(FR) PROCÉDÉS POUR EMPÊCHER DES DÉFAUTS DE TUBE NEURAL DANS UNE GROSSESSE DIABÉTIQUE
Abstract:
(EN) The invention provides compositions and methods for modulating levels of autophagy, as well as methods for preventing hyperglycemia-induced neural tube defects through administration of modulators of autophagy.
(FR) L'invention concerne des compositions et des procédés pour moduler des niveaux d'autophagie, ainsi que des procédés pour prévenir des défauts de tube neural induits par l'hyperglycémie, par l'administration de modulateurs de l'autophagie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)