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1. (WO2018204777) METHODS FOR IDENTIFICATION AND MODIFICATION OF LNCRNA ASSOCIATED WITH TARGET GENOTYPES AND PHENOTYPES

Pub. No.:    WO/2018/204777    International Application No.:    PCT/US2018/031075
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sat May 05 01:59:59 CEST 2018
IPC: A61P 35/00
Applicants: THE BROAD INSTITUTE, INC.
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors: JOUNG, Julia
ENGREITZ, Jesse
LANDER, Eric S.
ZHANG, Feng
Title: METHODS FOR IDENTIFICATION AND MODIFICATION OF LNCRNA ASSOCIATED WITH TARGET GENOTYPES AND PHENOTYPES
Abstract:
The application relates to methods for compositions for identifying IncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.