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1. (WO2018204702) PHOSPHATE FUNCTIONALIZED GRAPHENE OXIDE BASED BONE SCAFFOLDS

Pub. No.:    WO/2018/204702    International Application No.:    PCT/US2018/030967
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri May 04 01:59:59 CEST 2018
IPC: A61F 2/28
A61L 27/08
A61L 27/12
C01B 32/198
Applicants: ARNOLD, Anne M.
HOLT, Brian D.
SYDLIK, Stefanie A.
LAURENCIN, Cato T.
DANESHMANDI, Leila
Inventors: ARNOLD, Anne M.
HOLT, Brian D.
SYDLIK, Stefanie A.
LAURENCIN, Cato T.
DANESHMANDI, Leila
Title: PHOSPHATE FUNCTIONALIZED GRAPHENE OXIDE BASED BONE SCAFFOLDS
Abstract:
A method for functionalizing graphene oxide includes reacting graphene oxide with a phosphite compound and a metal salt in the presence of a Lewis acid to produce phosphate functionalized graphene oxide including ions of the metal. An apparatus includes a bone scaffold construct formed of phosphate functionalized graphene oxide including metal ions. A bone scaffold construct includes a graphene oxide material formed in the shape of the bone scaffold construct, the graphene oxide material including graphene oxide, phosphate moieties covalently bound to the graphene oxide, and metal counter ions chemically associated with the phosphate moieties. A method for treating a bone defect includes administering a therapeutically effective amount of phosphate functionalized graphene oxide including metal ions.