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1. (WO2018204691) METHODS AND ENZYME CATALYSTS FOR THE SYNTHESIS OF NON-CANONICAL AMINO ACIDS
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Pub. No.: WO/2018/204691 International Application No.: PCT/US2018/030951
Publication Date: 08.11.2018 International Filing Date: 03.05.2018
IPC:
A23L 1/226 (2006.01) ,A23L 27/20 (2016.01) ,C07H 21/04 (2006.01) ,C12N 1/15 (2006.01)
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
22
Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes
226
Synthetic spices or flavouring agents or condiments
[IPC code unknown for A23L 27/20]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
Applicants:
BOVILLE, Christina E. [US/US]; US
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; 1200 East California Boulevard Pasadena, CA 91125, US
Inventors:
BOVILLE, Christina E.; US
BRINKMANN-CHEN, Sabine; US
BULLER, Andrew, R.; US
ROMNEY, David, K.; US
PRIER, Christopher, K.; US
KOCH, Philipp; US
SCHEELE, Remkes; US
Agent:
PRESLEY, Andrew, D.; US
HAO, Joe, C.; US
SNYDER, Joseph, R.; US
MATHISON, Mark, P.; US
NJEIM, Patrick, M.; US
ROBERTS, Byron, N.; US
Priority Data:
62/500,69803.05.2017US
Title (EN) METHODS AND ENZYME CATALYSTS FOR THE SYNTHESIS OF NON-CANONICAL AMINO ACIDS
(FR) PROCÉDÉS ET CATALYSEURS ENZYMATIQUES POUR LA SYNTHÈSE D'ACIDES AMINÉS NON CANONIQUES
Abstract:
(EN) The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.
(FR) La présente divulgation porte sur des procédés de préparation de composés de tryptophane β-substitués. Les procédés comprennent : la combinaison de i) un indole non substitué ou un indole substitué, ii) une sérine β-substituée, et iii) un sous-motif β de tryptophane synthase (à savoir, TrpB); et le maintien du mélange obtenu dans des conditions suffisantes pour former le tryptophane β-substitué. Le TrpB contient au moins une mutation d'acide aminé qui favorise la formation d'un intermédiaire amino-acrylate. De nouveaux variants de TrpB et de nouveaux analogues de tryptophane β-substitués sont en outre décrits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)