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1. (WO2018204617) STABLE FORMULATIONS OF FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN

Pub. No.:    WO/2018/204617    International Application No.:    PCT/US2018/030851
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri May 04 01:59:59 CEST 2018
IPC: A61K 9/08
A61K 38/39
A61K 47/18
A61K 47/26
A61P 21/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: NASHINE, Vishal, C.
PATEL, Rushikesh, K.
Title: STABLE FORMULATIONS OF FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN
Abstract:
The present invention relates generally to stable liquid formulations comprising polypeptides with 10Fn3 domains which bind to myostatin and unit dosage forms thereof for administration various routes, including subcutaneous (SC), for treating muscle- wasting and metabolic disorders.