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1. (WO2018204603) PROPIONYL-CoA CARBOXYLASE COMPOSITIONS AND USES THEREOF
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Pub. No.: WO/2018/204603 International Application No.: PCT/US2018/030826
Publication Date: 08.11.2018 International Filing Date: 03.05.2018
IPC:
A61K 38/51 (2006.01) ,A61K 38/53 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
51
Lyases (4)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
53
Ligases (6)
Applicants:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US/US]; 1800 Grant Street 8th Floor Denver, CO 80203, US
Inventors:
KRAUS, Jan, P.; US
MAJTAN, Tomas; US
COLLARD, Renata; US
Agent:
WARD, Donna, T.; US
STANFORD, Anna, E.; US
Priority Data:
62/500,96703.05.2017US
Title (EN) PROPIONYL-CoA CARBOXYLASE COMPOSITIONS AND USES THEREOF
(FR) COMPOSITIONS DE PROPIONYL-COA CARBOXYLASE ET LEURS UTILISATIONS
Abstract:
(EN) The invention provides compositions of recombinant human propionyl-CoA carboxylase (PCC), conjugated PCC subunits, including PCCA and PCCB, and pharmaceutical compositions of the foregoing. Also included are methods for treating conditions such as propionic acidemia (PA), propionic aciduria, propionyl-CoA carboxylase deficiency and ketotic glycinemia using the compositions of the invention.
(FR) L'invention concerne des compositions de propionyl-CoA carboxylase humaine recombinante (PCC), des sous-unités PCC conjuguées, comprenant PCCA et PCCB, et des compositions pharmaceutiques de ces dernières. L'invention concerne également des méthodes permettant de traiter des états pathologiques tels qu'une acidémie propionique (PA), une acidurie propionique, un déficit en propionyl-CoA carboxylase et une glycinémie cétosique à l'aide des compositions selon l'invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)