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1. (WO2018204598) METHODS FOR DIAGNOSING OR PREDICTING CHRONIC BRONCHITIS

Pub. No.:    WO/2018/204598    International Application No.:    PCT/US2018/030820
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri May 04 01:59:59 CEST 2018
IPC: G01N 33/68
A61K 31/047
A61K 31/14
A61P 11/00
G06F 19/12
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors: KESIMER, Mehmet
Title: METHODS FOR DIAGNOSING OR PREDICTING CHRONIC BRONCHITIS
Abstract:
The present invention is directed to the use of (1) mucin concentration in sputum; (2) individual airway mucins MUC5AC and MUC5B ratio (MUC5AC/MUC5B) in sputum; and (3) combination of both measurements (Kesimer MUCQuant index) that can be used as an objective biomarker for differential diagnosis of smoking status and chronic bronchitis (CB), disease severity of CB (mild, moderate, and severe), exacerbation status, monitoring progression of CB, and guiding of therapies for CB. In addition, the ratio of amount of IgGFc-binding protein (FCGBP) and the amount of bactericidal/permeability- increasing fold-containing family member Al (BPIFA1 (or SPLUNC1)) present in a sputum sample from a subject may be used in combination with the Kesimer MUCQuant index (Kesimer MUCQuant Plus index) for differential diagnosis of smoking status and CB, disease severity of CB, exacerbation status, monitoring progression of CB, and guiding of therapies for CB.