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1. (WO2018204534) LAMP (LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN) CONSTRUCTS COMPRISING CANCER ANTIGENS

Pub. No.:    WO/2018/204534    International Application No.:    PCT/US2018/030725
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: A61K 39/00
Applicants: IMMUNOMIC THERAPEUTICS, INC.
Inventors: HEILAND, Teri
Title: LAMP (LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN) CONSTRUCTS COMPRISING CANCER ANTIGENS
Abstract:
The present invention provides LAMP Constructs comprising specific fragments of the LAMP lumenal domain to deliver cancer antigens to immune cells for enhanced processing. These LAMP Constructs can be used for the treatment of disease and in particular hyperproliferative disorders and/or cancer. The LAMP Constructs allow for presentation of properly configured three dimensional epitopes for production of an immune response when administered to a subject. The LAMP Constructs can be multivalent molecules, and/or can be provided as part of a multivalent vaccine containing two or more LAMP Constructs. The LAMP Constructs as described herein can also be used to generate antibodies when administered to a non-human vertebrate.