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1. (WO2018204445) PACKAGING FOR DRY TISSUE PROSTHETIC HEART VALVE

Pub. No.:    WO/2018/204445    International Application No.:    PCT/US2018/030575
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: B65D 81/18
A61F 2/00
B65D 81/22
A61F 2/24
Applicants: MEDTRONIC VASCULAR INC.
Inventors: RYAN, Raymond
CLARKE, David
GARDE, Kshitija
GUO, Ya
WONG, Benjamin
DAREKAR, Yogesh
LEHMANN, Luke
WANG, Wei, (will)
MCKINLEY, Laura
DEVEREUX, Paul
DUDNEY, Joshua
TIEN, Tracey
OLNEY, Karl
Title: PACKAGING FOR DRY TISSUE PROSTHETIC HEART VALVE
Abstract:
A "dry" packaging in which a prosthetic heart valve is packaged within a container with hydrogel (116) that can be provided in many forms. Certain embodiments include hydrogel (116) that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel (116) is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.