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1. (WO2018204413) TARGETED CYTOKINE BLOCKADES FOR CAR-T THERAPY

Pub. No.:    WO/2018/204413    International Application No.:    PCT/US2018/030526
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: C12Q 1/68
G01N 33/53
G01N 33/00
A61K 39/00
A61K 48/00
A61K 31/58
A61K 31/40
Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors: DAVILA, Marco L.
Title: TARGETED CYTOKINE BLOCKADES FOR CAR-T THERAPY
Abstract:
Disclosed are compositions and methods for detecting the cytokines upregulated in cytokine release syndrome and neurotoxicities associated with chimeric antigen receptor (CAR) T cell (CAR-T cell) toxicity and methods of targeted treatment of cytokines associated with the same. Specifically, the methods comprising: a) obtaining a tissue sample from a subject; b) performing an immunoassay that measures cytokines on the tissue sample; c) obtaining a cytokine profile for the subject; and d) adjusting therapy based on the cytokine profile.