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1. (WO2018204412) SYSTEMS-LEVEL ANALYSIS OF TCGA CANCERS REVEALS DISEASE TRNA FRAGMENTATION PATTERNS AND ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT

Pub. No.:    WO/2018/204412    International Application No.:    PCT/US2018/030525
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: C12N 15/113
C12Q 1/68
G01N 33/50
Applicants: THOMAS JEFFERSON UNIVERSITY
Inventors: RIGOUTSOS, Isidore
TELONIS, Aristeidis G.
Title: SYSTEMS-LEVEL ANALYSIS OF TCGA CANCERS REVEALS DISEASE TRNA FRAGMENTATION PATTERNS AND ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT
Abstract:
Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.