Search International and National Patent Collections

1. (WO2018204392) TUMOR ASSOCIATED MONOCYTE/MACROPHAGE BINDING PEPTIDE AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/204392    International Application No.:    PCT/US2018/030498
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: C07K 7/06
A61K 38/04
Applicants: STANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors: PANG, Hongbo
RUOSLAHTI, Erkki
Title: TUMOR ASSOCIATED MONOCYTE/MACROPHAGE BINDING PEPTIDE AND METHODS OF USE THEREOF
Abstract:
Disclosed are compositions and methods useful for targeting molecules to activated macrophages, such as tumor associated macrophages. The compositions and methods are based on peptide sequences, such as AMT peptides, that home to activated macrophages. The disclosed homing to activated macrophages is useful for delivering therapeutic and detectable agents to cells and tissues where immune system effects or inflammation are occurring.