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1. (WO2018204381) POLYMERIC CARRIERS AND METHODS

Pub. No.:    WO/2018/204381    International Application No.:    PCT/US2018/030479
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: C12N 5/00
C12N 5/0775
Applicants: BRIGHAM AND WOMEN'S HOSPITAL
LONZA WALKERSVILLE INC.
Inventors: ZHANG, Yi
ARTZI, Natalie
WANG, Kui
ABRAHAM, Eytan
LEVINSON, Yonatan
Title: POLYMERIC CARRIERS AND METHODS
Abstract:
Provided are methods of controlling disassociation of cells from a carrier, compositions, and methods of collecting cells. The methods of controlling disassociation of cells from a carrier may include contacting a polymeric carrier with one or more digesting agents to disassociate at least a portion of a plurality of cells from the polymeric carrier. The polymeric carrier may be crosslinked with a crosslinker including at least one of a redox sensitive moiety, a UV light sensitive moiety, a pH sensitive moiety, and a temperature sensitive moiety.