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1. (WO2018204363) ANTI-TIGIT ANTIBODIES AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/204363    International Application No.:    PCT/US2018/030453
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: A61K 39/395
C07K 16/28
A61K 39/00
Applicants: AGENUS INC.
Inventors: CHAND, Dhan, Sidhartha
WILSON, Nicholas, Stuart
UNDERWOOD, Dennis, John
MORIN, Benjamin, Maxime
Title: ANTI-TIGIT ANTIBODIES AND METHODS OF USE THEREOF
Abstract:
The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.