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1. (WO2018204323) USE OF DIANHYDROGALACTITOL OR ANALOGS AND DERIVATIVES IN COMBINATION WITH VEGF INHIBITORS TO TREAT CANCER
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Pub. No.: WO/2018/204323 International Application No.: PCT/US2018/030391
Publication Date: 08.11.2018 International Filing Date: 01.05.2018
IPC:
A61K 39/00 (2006.01) ,A61K 31/335 (2006.01) ,C07D 303/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
303
Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
02
Compounds containing oxirane rings
12
with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
Applicants:
DEL MAR PHARMACEUTICALS (BC) LTD. [CA/CA]; CA
Inventors:
BACHA, Jeffrey, A.; CA
BROWN, Dennis, M.; US
STEINØ, Anne; CA
Agent:
GALL, Anna, S.; US
Priority Data:
62/492,64701.05.2017US
62/660,02919.04.2018US
Title (EN) USE OF DIANHYDROGALACTITOL OR ANALOGS AND DERIVATIVES IN COMBINATION WITH VEGF INHIBITORS TO TREAT CANCER
(FR) UTILISATION DE DIANHYDROGALACTITOL OU D'ANALOGUES ET DÉRIVÉS EN ASSOCIATION AVEC DES INHIBITEURS DU VEGF POUR TRAITER LE CANCER
Abstract:
(EN) Methods and compositions employing dianhydrogalactitol or a derivative or analog of dianhydrogalactitol together with a vascular endothelial growth factor (VEGF) inhibitor or other anti-neoplastic agents can be used for treatment of glioma. In particular, methods and compositions according to the invention can decrease the invasiveness of gliomas. Further disclosed are methods of using the compositions for treating a malignancy that has failed a VEGF inhibitor treatment.
(FR) L'invention concerne des méthodes et des compositions utilisant du dianhydrogalactitol ou un dérivé ou analogue du dianhydrogalactitol en association avec un inhibiteur du facteur de croissance endothéliale vasculaire (VEGF) ou d'autres agents anti-néoplasiques, qui peuvent être utilisées pour le traitement du gliome. En particulier, les méthodes et compositions de l'invention peuvent diminuer l'invasivité de gliomes. L'invention concerne également des méthodes d'utilisation des compositions permettant de traiter une tumeur maligne qu'un inhibiteur du VEGF a échoué à traiter.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)